The following examples give a brief presentation of applications of Dextrans in Dextran derivates.
Dextran is an important starting material for Iron Dextran synthesis. Iron Dextran solution for injection is applied for treatment of human and veterinary anemic iron deficiency.
DEAE Dextrans (diethylaminoethyl Dextrans) are obtained from synthesis of diethylaminoethyl chloride with Dextrans. The DEAE Dextran polycations prepared from Dextran 500 fractions have reportedly been shown to reduce serum cholesterol and triglycerides. Emphasis on both quality and purity of Dextrans used for synthesis of derivates of Dextrans is critical for end-product quality and reproducibility.
Dextran Sulfate (Dextran Hydrogen Sulfate, sodium salt) is a polyanionic Dextran derivative, which may be synthesized from various high purity and well-characterized Dextran fractions. In clinical research anticoagulant Dextran Sulfate properties have been tested as a possible substitute for heparin in anticoagulant therapy. Another source of interest relates to the effect of Dextran Sulfate on enzyme inhibition in certain biological systems.