Stability of Dextran
Dry Substance Dextran Powder
Dextran fractions are stable for more than 5 years when stored as a dry substance Dextran powder in well-sealed containers at room temperature. Dextran powder will slowly absorb moisture when exposed to air or when stored in non-air tight containers.
Dextran Solutions and Sterilization
Dextran solutions may be sterilized by heating in an autoclave. These solutions are stable for many years and are best stored at constant temperature. The optimal pH for storage is between 6–7. However, Dextran is stable at ambient temperatures for extended periods in the pH range 4–10. Other techniques for sterilization of Dextran solutions, for example irradiation, may lead to degradation.
During autoclaving a slight decrease in pH and a slight yellowing may be observed, which does not affect Dextran fraction solutions or performance. The sterilization of Dextran solutions does not affect the molecular weight distribution of the Dextran.